Saturday, 14 July 2018

Modelling and Optimization of Biogenic Synthesis of Gold Nanoparticles from Leaf Extract of Swertia chirata Using Artificial Neural Network

Journal of Cluster Science (2018) 29:1151–1159

Swertia chirata is a medicinal plant studied for its ability to synthesize polyshaped gold nanoparticles (AuNP). The process of AuNP biosynthesis was studied using artificial neural networks (ANN) with different activation function on output node (logistic or linear) and different training algorithm (back propagation or Levenberg–Marquardt). The maximum biosyn- thesis was checked under the optimized condition of 17.24% leaf extract, pH 4.61, gold chloride concentration 4 mM and temperature 53.61 °C. A significant improvement in the model efficiency for predicting AuNP biosynthesis around 37.60%, in terms of root mean square error was obtained with the developed ANN-linear2 model, compared to the traditional response surface methodology.